Extended Data Fig. 1: Characterization of PD-1+ T-ALL cells. | Nature Cell Biology

Extended Data Fig. 1: Characterization of PD-1+ T-ALL cells.

From: PD-1 signalling defines and protects leukaemic stem cells from T cell receptor-induced cell death in T cell acute lymphoblastic leukaemia

Extended Data Fig. 1: Characterization of PD-1+ T-ALL cells.

Schematic depiction (top) and the representative FCAS plots (bottom) for the NOTCH1-induced T-ALL model. Hematopoietic stem and progenitor cells (HSPCs, Lin–Sca1+C-Kit+ cells) were enriched at d5.5 after 5FU treatment. HSPCs were infected with the NOTCH1 (co-expressed with GFP) virus, and the GFP+ T-ALL cells were analyzed after infection, and in the bone marrow of recipients at indicated days after transplantation. Plots are representative of n = 3 biological repeats.

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