Extended Data Fig. 8: SARS-CoV-2 infection induces senescence in COVID-19 patients’ lungs.
A) Representative IHC images of lung tissues stained for the senescence markers P16 (n = 5) or P21 (non-COVID individuals: n = 5; COVID-19 patients: n = 10); the presence of the virus was assessed by staining for SARS-CoV-2 N or by probing the viral genome through RNA ISH; nuclei were stained with hematoxylin (light blue); scale bar, 50 μm. Conditions are as in Fig. 8A. B) Quantification of the expression of the senescence markers determined in A. Values are the means ± s.e.m.; each dot corresponds to one individual. Source numerical data are available in source data. C) Gating strategy for flow cytometry.
