Extended Data Fig. 6: GINS organoids are not fully mature.
From: Stomach-derived human insulin-secreting organoids restore glucose homeostasis
a, Volcano plot comparing gene expression of GINS β-like cells (n = 2 independent batch of organoids, one representative batch is shown, donor #6) versus islet β cells (n = 4 independent donors, an integration of all samples) identified in Fig. 3a. The number of differentially expressed genes (DEGs) enriched in either cell group is shown in the plot. Threshold of DEGs: adjusted-P < 0.01 and log2 fold-change > 1. P-value calculated by Wilcoxon Rank Sum test and adjusted based on Bonferroni correction. b, Gene Ontology (GO) analysis of DEGs enriched in GINS β-like cells (blue) or islet β-cells (red). P-value calculated by hypergeometric distribution followed by Benjamini-Hochberg adjustment.
