Extended Data Fig. 9: Characterization of the developmental path of GINS organoids.
From: Stomach-derived human insulin-secreting organoids restore glucose homeostasis
a, Heatmap showing waves of transcription factor regulon activations. Key regulons are labeled on the right with the number of their predicted target genes. Stem: hGSCs; Endo 1: endocrine progenitors 1; Endo 2: endocrine progenitors 2; GINS pre: GINS precursors. b, Select regulon activity overlaid on UMAP. c, RNA velocity and pseudotime trajectory analysis in UMAP showing the developmental path from GINS precursors to endocrine cells in GINS organoids. a, b, n = 1, donor #6.
