Extended Data Fig. 6: Single-nucleus assays showing angiogenesis dysregulation in fibroblast and endothelial cell types. | Nature Cell Biology

Extended Data Fig. 6: Single-nucleus assays showing angiogenesis dysregulation in fibroblast and endothelial cell types.

From: Single-cell analysis reveals transcriptomic and epigenomic impacts on the maternal–fetal interface following SARS-CoV-2 infection

Extended Data Fig. 6: Single-nucleus assays showing angiogenesis dysregulation in fibroblast and endothelial cell types.

a, GO of upregulated genes in villous endothelial (V.Endo; left) and villous fibroblast 1 (V.FB1; right) cells from the snRNA-seq without the Cov7 (hypertension sample). The colour scale represents the ratio of dysregulated genes to total genes under each GO term; P values were calculated using a one-tailed hypergeometric test. b, Genome browser screenshot of the region around ENG. All pseudo-bulk tracks are displayed as RPM with y axes ranging from zero to two. c, Expression of hypoxia-related genes from the bulk RNA-seq. The fold change (patient/control) and Padj (two-tailed Wald test) were calculated by DESeq2. The genes that are significantly dysregulated (|log2(fold change)| > 1 and Padj < 0.05) are marked by a red star.

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