Fig. 5: DMRT1 targets for foetal germline development.

a, Venn diagram for comparing week 7 and week 9 upregulated PGC DEGs that are targets of DMRT1 identified by C&R. Text boxes indicate representative DMRT1 target PGC genes shared or unique in week 7 and week 9 male PGCs. b, Pie chart presents the distribution of genomic features for DMRT peaks (n = 384) associated with PGC genes. The percentage (%) of the target peaks is shown for each category. c, Proportion (y axis, %) of DMRT1 targets in d4 DZ⁺PGCLCs within the marker genes for migratory (18%; 26/142 genes), mitotic (16%: 47/288) or mitotic arrest (33%: 310/937 genes) PGCs. d, Proportion of DMRT1 targets for upregulated (Up, orange), not significant (NS, grey) and downregulated (Down, blue) genes for migratory, mitotic or mitotic arrest PGC in d4 DZ⁺PGCLCs versus 4i ES cells. e, Topmost commonly known motifs enriched in DMRT1 peaks. Left: motifs enriched in DMRT1 peaks associated with marker genes for migratory and mitotic male PGCs. Right: motifs enriched in DMRT1 peaks associated with marker genes for mitotic arrest male PGCs. Enrichment P values are calculated using binomial distributions. The data in a–e represent an integration of three biological replicates.