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A guide to studying mitochondria transfer

Nature Cell Biology volume 25, pages 1551–1553 (2023)Cite this article

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Mitochondria can shuttle between adjacent cells or travel to distant organs by breaking away from the parent cell and entering the circulation. Here, we briefly review the state of research into mitochondria transfer, and discuss a methodological framework for studying the process.

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Fig. 1: Methodologies for establishing mitochondria transfer mechanisms.

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Acknowledgements

S.T. and C.C. and are supported by the National Institutes of Health (NIH) (grant R00-DK122019) and the American Heart Association (23IPA1054013). J.R.B. is supported by the NIH Office of the Director (DP5 OD028125) and Burroughs Wellcome Fund (CAMS 1019648).

Author information

Authors and Affiliations

  1. Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, USA

    Snigdha Tiash & Clair Crewe

  2. Department of Internal Medicine, Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St. Louis, MO, USA

    Snigdha Tiash & Clair Crewe

  3. Department of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine, St. Louis, MO, USA

    Jonathan Robert Brestoff

Authors
  1. Snigdha Tiash
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  2. Jonathan Robert Brestoff
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  3. Clair Crewe
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Corresponding authors

Correspondence to Jonathan Robert Brestoff or Clair Crewe.

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Competing interests

J.R.B. has pending and issued patents related to mitochondria transfer and obesity; has been a consultant for DeciBio and Flagship Pioneering within the past 12 months; receives royalties from Springer Nature; and is on the Scientific Advisory Board for LUCA Science.

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Nature Cell Biology thanks Martin Picard, Carlos Moraes and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.

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Tiash, S., Brestoff, J.R. & Crewe, C. A guide to studying mitochondria transfer. Nat Cell Biol 25, 1551–1553 (2023). https://doi.org/10.1038/s41556-023-01246-1

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