Extended Data Fig. 4: Selective, binary regulation of lipoprotein transport by adenovirus.
From: Manganese regulation of COPII condensation controls circulating lipid homeostasis
a, Representative EM negative staining images of plasma lipoproteins purified from mice with indicated genotypes and treatments. b, IB of liver samples from mice with the indicated genotypes and treatments. c, Quantification of IB signals of APOB and ALB in (b). n = 3 biological independent sample. Data are shown as mean ± SEM. P values were determined by unpaired two-sided Student’s t-test. d, Confocal images of SEC31A in primary hepatocytes treated with or without AdV. The nucleus is highlighted with a yellow dashed line. e, Confocal images of SEC24A and SURF4 in primary hepatocytes treated with or without AdV. The nucleus is highlighted with a white dashed line. For a-e, Representative of 3 biological independent experiments is shown. Scale bars, 200 nm (a), or 5μm (d-e). Source numerical data and unprocessed blots are available in Source Data.
