Extended Data Fig. 5: Role of SPE-8-group genes in mitopherogenesis.
(a) A graph showing that sperm-specific expression of SPE-8 reverses the reduction in mitophers number in the spe-8(lf). Is[spe-11p::SPE-8];spe-8(lf) males show increased mitophers generation relative to the spe-8(lf) mutant males. Promoter of spe-11 drives the expression of the transgene specifically in the sperm. n = 30,000 spermatids were analysed. (b,c) Bar graphs showing that spe-27(lf);spe-29(lf) and spe-29(lf) mutations exhibit no obvious effect on number of in vivo mitopher in the male testis. n = 15,000 spermatids in (b) and n = 30,000 spermatids in (c) were analysed. The number of biologically independent experiments is 6 in (a,c), 3 in (b). Source numerical data are available in source data.
