Extended Data Fig. 9: Analysis of less accessible transcription factor binding motifs in mouse prostate organoids treated with UK5099 or lactate supplementation. | Nature Cell Biology

Extended Data Fig. 9: Analysis of less accessible transcription factor binding motifs in mouse prostate organoids treated with UK5099 or lactate supplementation.

From: Prostate lineage-specific metabolism governs luminal differentiation and response to antiandrogen treatment

Extended Data Fig. 9: Analysis of less accessible transcription factor binding motifs in mouse prostate organoids treated with UK5099 or lactate supplementation.

(a-b) Seven most significantly enriched transcription factor binding motifs in less accessible regions in organoids treated with 10 μM UK5099 (a) or 20 mM sodium lactate (b). The false discovery rate (FDR) was controlled using the Benjamini-Hochberg method. (c) Venn diagram depicting overlap in significantly enriched transcription factor binding motifs in less accessible regions in UK5099-treated and lactate-supplemented organoids. (d) Browser track depicting ATAC-seq peaks in Prom1 gene in vehicle-treated, UK5099-treated, and lactate-supplemented organoids.

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