Extended Data Fig. 8: The therapeutic benefit of NMTi in a model of bleomycin-induced lung fibrosis.
From: COPI vesicle formation and N-myristoylation are targetable vulnerabilities of senescent cells
a, Experimental design of the mouse model of bleomycin-induced lung fibrosis. All analyses were performed at 28 days after treatment with bleomycin (intratracheal 0.75 U/kg) into the lungs of 6-8 weeks old, C57BL/6 J male mice. b, Lung hydroxyproline content in samples from mice of the experiment described here. (n = 6 mice, vehicle; n = 8 mice, NMTi). c-j, Relative expression of the indicated mRNAs in lung samples (n = 6 mice, vehicle; n = 8 mice, NMTi). Data represented as mean ± SD throughout figure. Unpaired two-tailed t-test used throughout figure. N represents mice throughout figure. Source numerical data are available in source data.
