Extended Data Fig. 5: Single-cell RNA sequencing data show high expression of Epac1 specifically in cold-responsive PDGFRα+ brown preadipocytes. | Nature Cell Biology

Extended Data Fig. 5: Single-cell RNA sequencing data show high expression of Epac1 specifically in cold-responsive PDGFRα+ brown preadipocytes.

From: EPAC1 enhances brown fat growth and beige adipogenesis

Extended Data Fig. 5: Single-cell RNA sequencing data show high expression of Epac1 specifically in cold-responsive PDGFRα+ brown preadipocytes.

a, t-SNE plot generated from published data28 (GSE207707) showing the different adipose tissue stromal cells (ASC) and proliferating/differentiating adipocytes in control- and cold-exposed mice. b, t-SNE plots from the same dataset showing expression of Epac1 (Rapgef3) in the quiescent ASC1 population (in control mice) and the cold-activated ASC1 population (in cold-exposed mice). c, Dot-plot showing the relative expression of Epac1 (Rapgef3) in the different ASC populations. d, t-SNE plots showing expression of the preadipocyte marker Pdgfra and the mature adipocyte markers Plin1 and Ucp1.

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