Extended Data Fig. 7: Functional pathways enriched in domain-associated NMF gene modules in mouse and human.

a,b Selected enriched functional pathways in each NMF gene module displayed in Fig. 2e,f in (a) mouse and (b) human. All gene modules with a regionally variable expression profile across segments that contained genes that encode aspects of nutrient metabolism are displayed (8 modules per species, dotted vertical lines). Module labels (bottom) are the domain(s) most closely-associated with each module, as determined by regional expression profile and rank of key domain-associated signature genes. Pathways were edited to remove redundancy. P values were adjusted for multiple comparisons using the Benjamini-Hochberg procedure.