Extended Data Fig. 3: Zonation across multiple axes of the small intestine. | Nature Cell Biology

Extended Data Fig. 3: Zonation across multiple axes of the small intestine.

From: Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains

Extended Data Fig. 3: Zonation across multiple axes of the small intestine.The alternative text for this image may have been generated using AI.

a UMAP of absorptive lineage cells coloured by segment number along the proximal to distal axis in mouse and human donors. Major epithelial cell types are labeled. b-e Villus zonation across murine enterocytes. b UMAP plots coloured according to summed expression of previously reported21 landmarks of the villus tip (left) or base of villus (right). An equal number of enterocytes were assigned to each of 6 crypt:villus zones, zones 1–6. c UMAP plots coloured according to the expression of select top and bottom villus markers. d UMAP plots coloured according to villus zonation scores (left) compared to segment positions (right). Villus zonation scores represent the ratio of the summed expression of bottom and top landmark genes. e Expression of select villus zonation markers across crypt:villus zones. Center lines represent zone mean, and are coloured by domain with surrounding grey standard error bands. M-, microfold.

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