Extended Data Fig. 5: p300 shuttling is not mediated by known interactors or their activities. | Nature Cell Biology

Extended Data Fig. 5: p300 shuttling is not mediated by known interactors or their activities.

From: p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson–Gilford progeria syndrome

Extended Data Fig. 5

a, b, No effect in p300 nucleocytoplasmic shuttling by depleting BAG6 (a) or ALX1 (b) in AAs starved cells. * knockdown (KD) cells, #non-knockdown (Non-KD) cells. N = 4 or N = 3, respectively, about 50 cells scored per condition per experiment. Two-tailed paired t test. Scale bar, 5 μm, 2 μm (enlarged images). c, No change in p300 nucleocytoplasmic shuttling after treatment with a p300 activator (0.5 mM CTB) or a p300 inhibitor (20 μM c646). N = 3, about 50 cells scored per condition per experiment. Two-tailed paired t test. Scale bar, 5 μm. Data are presented as mean values +/- s.d. unless otherwise specified. Source numerical data are available in source data.

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