Extended Data Fig. 1: Cytidine editing outcome in-depth analyses.
From: C-to-G editing generates double-strand breaks causing deletion, transversion and translocation
a, Schematic illustration of the cytidine editing tools tested in the in-depth profiling assay. b, Substitution frequency (top) and C > G purity (bottom) of the indicated tools at 4 sgRNA targeting loci. Mean ± SEM of three biological replicates is shown. c, On-target deletion frequency at the 4 loci. Mean ± SEM of three biological replicates is shown. d, Representative western blot of BE expression from three replicates. e, Size distribution of on-target deletions. Mean ± SEM of three biological independent replicates are shown. f, Substitution and deletion profiles at the indicated loci after editing. Panel is labeled as Fig. 1f. Source numerical data and unprocessed blots are available in source data.
