Fig. 5: Basal process inheritance does not predict bRG fate on asymmetric division.

a, Live/fixed correlative analysis of basal process inheritance in a dividing bRG cell generating a process-inheriting bRG daughter and neuron, within a cerebral organoid. b, Live/fixed correlative analysis of basal process inheritance in a dividing bRG cell generating a process-inheriting IP daughter and a bRG daughter, within a cerebral organoid. c, Distribution of cell fates depending on process inheritance upon asymmetric cell division in week 8–10 cerebral organoids (N = 79 asymmetrically dividing cells from five experiments). d, Proportion of self-renewing versus differentiating daughter cells upon asymmetric division, depending on process inheritance in week 8–10 cerebral organoids (N = 79 asymmetrically dividing cells from five experiments). e, Live/fixed correlative analysis of basal process inheritance in a dividing bRG cell generating a process-inheriting bRG daughter and a neuron, within fetal frontal cortex. f, Live/fixed correlative analysis of basal process inheritance in a dividing bRG cell generating a process-inheriting IP daughter and a bRG daughter, within fetal frontal cortex. g, Distribution of cell fates depending on process inheritance upon asymmetric cell division in GW 14–17 human frontal cortex (N = 82 asymmetrically dividing cells from two experiments). h, Proportion of self-renewing versus differentiating daughter cells upon asymmetric division, depending on process inheritance in GW 14–17 human frontal cortex (N = 82 asymmetrically dividing cells from two experiments). All images are representative examples of experiments performed in at least three independent organoid batches and two independent fetal brains. N, neuron; D, differentiating daughter.