Extended Data Fig. 1: Other candidates from CRISPR screen hits do not correlate with the prognosis of AML patients. | Nature Cell Biology

Extended Data Fig. 1: Other candidates from CRISPR screen hits do not correlate with the prognosis of AML patients.

From: Phase separation-competent FBL promotes early pre-rRNA processing and translation in acute myeloid leukaemia

Extended Data Fig. 1: Other candidates from CRISPR screen hits do not correlate with the prognosis of AML patients.

a, Recipient mice developed myeloid leukemia after transplantation as determined by flow cytometry analysis of peripheral blood GFP+BFP+ MLL-AF9-transformed donor cells. b, Survival of primary (1st) and secondary (2nd) recipients transplanted with GFP+BFP+ cells. Log rank (Mantel–Cox) test. c and d, Depleted RBPs in the in vivo CRISPR KO screens. Selective known positive regulators of AML are highlighted. FC, fold change. Displayed results derive from MAGeCK’s negative binomial analysis, with one-sided p-values for sgRNA effects. e, Gene ontology analysis of depleted hits in the CRISPR screen. GOBP, gene ontology biological process terms. ClusterProfiler: The one-tailed Fisher’s exact test with FDR. f, Overall survival analysis of other top ranked nucleolar proteins indicate that their expression levels do not correlate with the prognosis in AML patients28. Log rank Mantel–Cox test.

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