Extended Data Fig. 4: Zeb1 regulates the expression of lipogenic enzymes crucial for adjusting the PUFA/MUFA ratio. | Nature Cell Biology

Extended Data Fig. 4: Zeb1 regulates the expression of lipogenic enzymes crucial for adjusting the PUFA/MUFA ratio.

From: Zeb1 mediates EMT/plasticity-associated ferroptosis sensitivity in cancer cells by regulating lipogenic enzyme expression and phospholipid composition

Extended Data Fig. 4: Zeb1 regulates the expression of lipogenic enzymes crucial for adjusting the PUFA/MUFA ratio.The alternative text for this image may have been generated using AI.

a) Simplified scheme of fatty acid biosynthesis pathways including relevant lipogenic enzymes. Note that most PUFAs, including those considered most relevant for the execution of ferroptosis (in bold) are not generated de novo, but are derived from essential fatty acids (C18:3 (ω-3) / linolenic acid and C18:2 (ω-6) / linoleic acid) taken up by the cell. b) Correlation of lipogenic enzymes with Zeb1 expression in 732 solid cancer cell lines from the CCLE database using cBioPortal (http://www.cbioportal.org/; https://sites.broadinstitute.org/ccle/). Shown are Spearman and Pearson correlations, derived from two-tailed t-test. c) IHC scores of indicated factors in allograft mouse tumours. Tumours were grouped in three different ways: 1. Zeb1-IHC Score (Zeb1low ≤ 1 vs Zeb1high > 1), 2. Zeb1 genotype (KPC, Zeb1 wt vs KPCZ, Zeb1ko), 3. histological tumour grade (low ≤ 2 vs high > 2). Bar graphs are presented as mean ± SD from n = 17 individual tumours, two-tailed unpaired student t-test.

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