Fig. 6: SCD inhibitors sensitize to ferroptosis in translationally relevant settings. | Nature Cell Biology

Fig. 6: SCD inhibitors sensitize to ferroptosis in translationally relevant settings.

From: Zeb1 mediates EMT/plasticity-associated ferroptosis sensitivity in cancer cells by regulating lipogenic enzyme expression and phospholipid composition

Fig. 6: SCD inhibitors sensitize to ferroptosis in translationally relevant settings.The alternative text for this image may have been generated using AI.

a,b, Reciprocal effect of SCD1 inhibition and FADS2 inhibition on TGFβ-induced ferroptosis sensitivity in A549 and H358 lung carcinoma cells. Relative cell viability of A549 (a) and H358 (b) cells that were stimulated with 5 ng ml−1 TGFβ for 4 and 9 days, respectively, then pretreated with 5 µM MF438 (left) or 10 µM sc-26196 (right) for 24 h, and exposed to the indicated concentrations of ML210 for 48 h (H358) or 72 h (A549). Data are presented as mean ± s.e.m. from n = 3 independent experiments; ordinary two-way ANOVA. c, Relative cell viability of control and erlotinib-resistant (TR) H358 cells treated with 5 µM MF438 (left) or 10 µM sc-26196 (right) for 24 h, followed by ML210 treatment for 72 h. Data are mean ± s.e.m. from n = 3 independent experiments; ordinary two-way ANOVA. NS, not significant.

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