Errors in chromosome segregation during cell division lead to changes in nuclear features. A study now shows that a mechanosensitive nuclear checkpoint activates the tumour suppressor p53 to halt the proliferation of aneuploid cells. These findings provide mechanistic insights to explore in both ageing and cancer pathologies.
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Macedo, J.C., da Silva, M.M. & Logarinho, E. Misshapen chromosomes in check by mechanics. Nat Cell Biol 27, 9–11 (2025). https://doi.org/10.1038/s41556-024-01573-x
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DOI: https://doi.org/10.1038/s41556-024-01573-x
