In each cell division during early embryogenesis, daughter cells acquire half the size of the mother cell. A study now reports that cytoplasmic flows sensing the cell boundaries allow daughter cells to adapt to their new size and reform their nuclear envelope in the right position.
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References
Schindler-Johnson, M. & Petridou, N. I. Front. Cell Dev. Biol. 12, 1358971 (2024).
Afonso, O., Dumoulin, L., Kruse, K. & Gonzalez-Gaitan, M. Nat. Cell Biol. https://doi.org/10.1038/s41556-024-01605-6 (2025).
Lu, W. & Gelfand, V. I. J. Cell Sci. 136, jcs260300 (2023).
Kimmel, C. B. et al. Dev. Dyn. 203, 253–310 (1995).
Afonso, O. et al. Science 345, 332–336 (2014).
Fuller, B. G. et al. Nature 453, 1132–1136 (2008).
Caballero-Mancebo, S. et al. Nat. Phys. 20, 310–321 (2024).
Deneke, V. E. et al. Cell 177, 925–941.e17 (2019).
Tominaga, M. et al. Dev. Cell 27, 345–352 (2013).
Ganguly, S., Williams, L. S., Palacios, I. M. & Goldstein, R. E. Proc. Natl Acad. Sci. USA 109, 15109–15114 (2012).
Shamipour, S. et al. Cell 177, 1463–1479.e18 (2019).
Pelletier, J. F., Field, C. M., Fürthauer, S., Sonnett, M. & Mitchison, T. J. eLife 9, e60047 (2020).
Tanimoto, H., Kimura, A. & Minc, N. J. Cell Biol. 212, 777–787 (2016).
Ben-Zvi, D., Shilo, B.-Z. & Barkai, N. Curr. Opin. Genet. Dev. 21, 704–710 (2011).
Lacroix, B. & Dumont, J. Cells 11, 248 (2022).
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Petridou, N.I. Flow, sense and divide. Nat Cell Biol 27, 176–177 (2025). https://doi.org/10.1038/s41556-024-01591-9
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DOI: https://doi.org/10.1038/s41556-024-01591-9