Extended Data Fig. 10: Perturb-seq derived gene signatures show cell-type-specific enrichment in Crohn’s disease. | Nature Cell Biology

Extended Data Fig. 10: Perturb-seq derived gene signatures show cell-type-specific enrichment in Crohn’s disease.

From: Systematic reconstruction of molecular pathway signatures using scalable single-cell perturbation screens

Extended Data Fig. 10: Perturb-seq derived gene signatures show cell-type-specific enrichment in Crohn’s disease.The alt text for this image may have been generated using AI.

The gene set enrichment test for DEG identified for patients with Crohn’s disease (CD) in an external dataset (Kong et al 2023 Immunity) (Methods). The analysis includes inflamed and non-inflamed tissues from CD patients. Each row indicates a gene set from our Perturb-seq data, and each column indicates a cell type from which the DEGs are obtained. Two-sided Fisher’s exact tests were used for the enrichment test. The enrichment test odds ratio is represented by the size of the dot, and the enrichment test adjusted P value (after Benjamini–Hochberg correction) is represented by the gradient of the colour. Adjusted P-values less than 0.01 are labelled by asterisk. Source numerical data are available in Source Data.

Source data

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