Extended Data Fig. 3: Differential localization of REM transcription factors at CLSY3 CLSY4-dependent siRNA sites. | Nature Cell Biology

Extended Data Fig. 3: Differential localization of REM transcription factors at CLSY3 CLSY4-dependent siRNA sites.

From: REM transcription factors and GDE1 shape the DNA methylation landscape through the recruitment of RNA polymerase IV transcription complexes

Extended Data Fig. 3: Differential localization of REM transcription factors at CLSY3 CLSY4-dependent siRNA sites.

a, Heatmaps showing enrichment of VDD, VAL, REM13, REM19, REM22 and REM8 ChIP-seq signal over three groups of CLSY3 CLSY4-dependent sites. The region is −2Kb to 2Kb from the center. Same regions were used for all metaplots. b, TOMTOM analysis showing the similarities of VDD, REM12 and REM13 binding sites with CLSY3 CLSY4 motif 1. E value is the expected number of false positives in the matches up to this point. c, Screenshot of REM22, VDD, VAL, REM13, REM19, REM8, GDE1, CLSY3, CLSY4 and Pol IV ChIP-seq at a distinct representative Group 1 of CLSY3 CLSY4-dependent siRNA sites, where REM22, but not other REM proteins exhibit enrichment. Square brackets indicate the range on a bar graph. d, RNA-seq expression analysis of REM transcription factors, GDE1, CLSY3 and CLSY4 in different tissues. e, Screenshot of REM8, REM19, VDD, VAL, REM13, REM22, GDE1, CLSY3, CLSY4 and Pol IV ChIP-seq at two representative Group 2 of CLSY3 CLSY4-dependent siRNA loci. Square brackets indicate the range on a bar graph.

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