Extended Data Fig. 8: Metabolic profile of AML-HSPCs.

a, PCA of AML and healthy HSPCs RNA-seq samples based on the top 500 most variable genes. n = 3–7. b, GSEA of GO processes on RNA-seq of TET2 mutated AML vs healthy HSPCs. P-adjusted value. c, GSEA of selected metabolic processes on RNA-seq of TET2 mutated AML vs healthy HSPCs. P-adjusted value. (a) n indicates the number of biological replicates per condition.