Fig. 6: CellNavi predicts driver genes in novel cell types. | Nature Cell Biology

Fig. 6: CellNavi predicts driver genes in novel cell types.

From: CellNavi predicts genes directing cellular transitions by learning a gene graph-enhanced cell state manifold

Fig. 6

a, UMAP visualization of transcriptomic profiles from ref. 67. Grey, HEK293FT cells used for model fine-tuning. Blue, K562 cells for model test. b, Predicted perturbations versus true perturbations in K562 cells. Each row represents a predicted perturbation, and each column represents a cell, whose true perturbation is labelled on top. Prob, probabilities of predicted perturbation. c, A heatmap showing average Pearson correlations over transcriptomic profiles between each pair of perturbations in K562 cells. d, A heatmap showing average Pearson correlations over transcriptomic profiles between predicted perturbations and true perturbations in K562 cells. Row, predicted perturbations. Column, true perturbations.

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