Glioblastoma (GBM) heterogeneity might arise because of the activation of various gene core regulatory circuitries (CRCs). A new study highlights the central role of HOXB3 in GBM CRCs and how peptide-mediated perturbation of HOXB3-related CRCs in GBM holds potential as treatment for a subset of patients.
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References
Price, B. et al. Neuro-Oncol. 26, iii1–iii85 (2024).
Xie, T. et al. Nat. Commun. 15, 3905 (2024).
Patel, A. P. et al. Science 344, 1396–1401 (2014).
Eisenbarth, D. & Wang, Y. A. Oncogene 42, 2155–2165 (2023).
Neftel, C. et al. Cell 178, 835–849 (2019).
Zhang, C. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-025-01758-y (2025).
Schaffner, W. Biol. Chem. 396, 311–327 (2015).
Hnisz, D. et al. Cell 155, 934–947 (2013).
Chen, Y. et al. Oncogene 39, 6633–6646 (2020).
Wu, S. J. et al. Nat. Biotechnol. 39, 819–824 (2021).
Bartosovic, M., Kabbe, M. & Castelo-Branco, G. Nat. Biotechnol. 39, 825–835 (2021).
Saint-André, V. et al. Genome Res. 26, 385–396 (2016).
Sabari, B. R. et al. Science 361, eaar3958 (2018).
Lu, B. et al. Adv. Sci. 8, 2101895 (2021).
Acknowledgements
G.C.-B. was supported by the Swedish Research Council (Distinguished Professor grant 2023-00324), the Swedish Cancer Society (Cancerfonden grant 232945 Pj 01 H) and the Knut and Alice Wallenberg Foundation (Wallenberg Scholar grant 2023-0280). Y.D was supported by a Swedish Cancer Society postdoctoral grant.
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G.C.-B. is a shareholder and board member at Nexus Epigenomics. The other authors declare no competing interests.
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Dang, Y., Lor, Y.K. & Castelo-Branco, G. Cracking glioblastoma core regulatory codes. Nat Cell Biol 27, 1600–1602 (2025). https://doi.org/10.1038/s41556-025-01780-0
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DOI: https://doi.org/10.1038/s41556-025-01780-0
