The regulatory mechanisms that drive oncogene expression in gliomas remain poorly understood. A study now identifies a role for widespread rearrangements of the enhancer connectome. Such rearrangements are linked to known genetic risk variants, revealing how genetic predisposition contributes to malignancy.
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Fratton, A., Bonev, B. Deciphering glioma susceptibility. Nat Cell Biol 27, 1603–1604 (2025). https://doi.org/10.1038/s41556-025-01782-y
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DOI: https://doi.org/10.1038/s41556-025-01782-y
