Phase separation is a mechanism for non-organellar macromolecule segregation typical in the cell cytosol and nucleus. Two recent studies revealed functional phase separation within the endoplasmic reticulum, where calcium-mediated condensates co-ordinate chaperones and disulfide catalysts to enhance secretory protein production.
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Fass, D., Sevier, C.S. Young secretory proteins go through a phase. Nat Cell Biol 27, 1887–1888 (2025). https://doi.org/10.1038/s41556-025-01800-z
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DOI: https://doi.org/10.1038/s41556-025-01800-z
