The endoplasmic reticulum (ER) is central to protein synthesis, folding and secretion. A study now shows that ageing is characterized by a striking loss of ER mass and remodelling of the ER structure. This shift is driven by tissue-specific ER-phagy, and may contribute to age-related loss of proteostasis.
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Lapenta, K., Parlakgül, G. & Arruda, A.P. ER gets out of shape with ageing. Nat Cell Biol (2026). https://doi.org/10.1038/s41556-025-01864-x
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DOI: https://doi.org/10.1038/s41556-025-01864-x
