Damaged mitochondria must be removed to preserve organelle function, and a quality control pathway segregates damaged peripheral subdomains into small MTFP1-enriched mitochondria targeted for degradation. A study now identifies MISO as the key factor that promotes subdomain formation and links mitochondrial dynamics, quality control and mtDNA homeostasis.
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Fontanesi, F. Mitochondrial quality control relies on MISO. Nat Cell Biol (2026). https://doi.org/10.1038/s41556-025-01866-9
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DOI: https://doi.org/10.1038/s41556-025-01866-9
