Extended Data Fig. 5: SP110 loss amplifies virus-induced cell death independent of SP100. | Nature Cell Biology

Extended Data Fig. 5: SP110 loss amplifies virus-induced cell death independent of SP100.

From: An SP110–SP100 axis is a critical regulator of promyelocytic leukaemia body dynamics and mitotic fidelity

Extended Data Fig. 5: SP110 loss amplifies virus-induced cell death independent of SP100.The alternative text for this image may have been generated using AI.

a. Validation of SP100 and SP110 expression status in A549 WT pool or isogenic knockout clones. GAPDH served as the loading control. b-d. Time course of A549 cells infected with (b) H5N1-GFP, (c) HSV-1-GFP, or (d) VSV-GFP. Left panels: Relative cell confluence as quantified microscopically by cell area. Right panels: Normalized viral replication as quantified by GFP fluorescence measured per well area. hpi = h post-infection. Data points denote mean ± s.d. (n = 2 independent biological replicates). Source numerical data and unprocessed blots are available in source data.

Source data

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