Extended Data Fig. 10: Mining co-regulatory protein networks to nominate disease gene candidates.
From: The proteomic landscape and temporal dynamics of human and mouse gastruloid development
(a) Number of cooperative disease proteins with physical evidence in BioPlex or BioGrid to known protein complexes. (b) Oxidative phosphorylation co-regulatory network (pathway associations curated from WikiPathways). Proteins associated with Leigh syndrome (blue stars) were enriched in the oxidative phosphorylation co-regulation network (Pathway curated from WikiPathways). (c) Temporal protein profiles of the Commander complex across human and mouse gastruloid development. (d) Boxplots comparing the distributions of minor axis length (left) and major-to-minor axis ratio (Eccentricity, right) of wild-type and perturbed gastruloids (n >= 8 for each genetic knockout). Significance determined using two-sided standard t-test. Boxplots show the median (centre line), 25th–75th percentiles (box), 1.5x the interquartile range (line; end points signify maxima and minima). Significance determined using two-sided standard t-test.
