Extended Data Fig. 2: Quantitative proteomics of human gastruloids expands protein coverage and recapitulates temporal trends observed during gastruloid differentiation.
From: The proteomic landscape and temporal dynamics of human and mouse gastruloid development
(a) Barplot of the number of proteins quantified in human and mouse gastruloids [this study] vs. mouse gastruloids [Stelloo et al.42]. (b) Venn diagram showing intersection of proteins detected in human gastruloids [this study], mouse gastruloids [this study], and mouse gastruloids [Stelloo et al.42]. (c) Proportion of the 7,352 proteins detected in human gastruloids [this study] also detected in published human and mouse embryo proteomics datasets42,43,44. (d) Left: Venn diagram showing intersection of proteins detected in human gastruloids [this study], mouse gastruloids [Stelloo et al.42], and mouse embryos [Stelloo et al.42]. Right: Comparison of temporal trends of selected proteins in mouse embryos (E7.5, E8.5, and E9.5; n >=3 for each stage) [Stelloo et al.42] vs. human gastruloid timepoints (primed, early, and late; n = 3 for each stage) [this study]. Significance computed through one-way ANOVA.
