Extended Data Fig. 7: Additional spatial analysis on gut tube development and PGC migration, related to Fig. 4. | Nature Cell Biology

Extended Data Fig. 7: Additional spatial analysis on gut tube development and PGC migration, related to Fig. 4.

From: A three-dimensional spatial transcriptome atlas reconstructs early organogenesis in primate Carnegie stages 9 and 10 embryos

Extended Data Fig. 7: Additional spatial analysis on gut tube development and PGC migration, related to Fig. 4.The alternative text for this image may have been generated using AI.

a, Spatial expression of representative PGC markers on endodermal clusters of 3D reconstructed CS9 cynomolgus monkey embryo. b, Spatial expression of representative PGC markers on endodermal clusters of 3D reconstructed CS10 cynomolgus monkey embryo. c, Dotplot depicting the expression of chemokine and chemokine receptors in gut tube-related subclusters. d, Spatial expression of CXCR4 and CXCL12 on gut tube clusters of CS9 and CS10 cynomolgus monkey embryos. e, Immunofluorescence analysis of CS9 cynomolgus monkey embryo slice for NANOG, SOX17 and CXCR4. White box on the leftmost panel indicates the region magnified for locating PGCs. Red arrows indicate CXCR4-expressing PGCs (n = 1 embryo). Scale bar, 100 μm. f, Immunofluorescence analysis of CS9 cynomolgus monkey embryo slice for OCT4, SOX17 and CXCR4. White box on the leftmost panel indicates the region magnified for locating PGCs. Red arrows indicate CXCR4-expressing PGCs (n = 1 embryo). Scale bar, 100 μm.

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