Extended Data Fig. 3: Impact of gut bacterial drug metabolism on GPCR activity.
From: Activity of GPCR-targeted drugs influenced by human gut microbiota metabolism
(a) Sample preparation procedure for GPCR activity tests. (b) GPCR activity of 12 drugs were tested and compared under two conditions: drugs were administered without undergoing metabolism (at 0 h, blue), and drugs undergoing complete metabolization (at 24 h, red). Drug activities were quantified by EA50 values, Log10[Conc, M] refers to the starter drug concentration of 10 μM in the complex medium extracts. n = 3 biological replicates. Data are means ± SEM.
