Extended Data Fig. 6: Mapping drug metabolism by individual bacterial species.
From: Activity of GPCR-targeted drugs influenced by human gut microbiota metabolism
(a) Selected 12 isolates from bacterial collection represent their corresponding clades for the examination of drug metabolism. Proteobacteria, red; Actinobacteria, purple; Bacteroidetes, green; Firmicutes, blue. Mono bacterial drug metabolism for azilsartan medoxomil (b), olmesartan medoxomil (c), sarpogrelate (d), fesoterodine (e), selexipag (f), ozanimod (g), GSK1292263 (h), ponesimod (i), and iloperidone (j). No significant O-demethylation metabolism of the three drugs (trimebutine, trimethobenzamide, and SB756050) was detected in the 12 selected bacterial isolates. Further details are provided in Supplementary Fig. S81. n = 3 biological replicates. Data are means ± SEM.
