Extended Data Fig. 6: Diagnostic shifts in the NMR spectra upon Friedländer macrocyclization.
From: Chemical and ribosomal synthesis of atropisomeric and macrocyclic peptides with embedded quinolines
a, Proton NMR of LP4 (red) and CP4 (teal) show the emergence of a distinct set of downfield aromatic protons (blue box) corresponding to the quinoline ring protons. b, gCOSY NMR spectra of LP4 (red, left) and CP4 (teal, right) display the correlated spin-couplings of the quinoline system. c, Carbon NMR of LP4 (red) and CP4 (teal) show the distinct loss of two ketone carbons around 200-210 ppm. Note: the tops of the solvent residuals have been truncated to save space; the truncation point is indicated with a dashed line.
