Extended Data Fig. 3: Extracted ion chromatograms of Friedländer reactions of peptides synthesized using in vitro translation (IVT) methods.
From: Chemical and ribosomal synthesis of atropisomeric and macrocyclic peptides with embedded quinolines
a-d, Extracted mass chromatograms for 2-P1 (highlighted in grey) and each quinoline peptide (pink) after reaction in AcOH at 40 °C for 24 h. e, Extracted mass chromatograms for 2-P1 (grey) and presumed atropisomer quinoline peptide Q26-P1 (teal) after reaction in AcOH or in the presence of Yb(OTf)3 in EtOH or in MeCN. All reactions were run for 24 h at 40 °C.
