Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Electron crystallography

Determining chirality in crystalline powders through 3D electron diffraction

Determining the enantiomorphic excess in chiral solids remains a difficult task, yet it is crucial for the characterization of materials such as chiral catalysts. Now, a combination of 3D electron diffraction, dynamical diffraction calculations, and automated processing enables the quantification of enantiomorphs in a fast and reliable manner.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Workflow of the method for the high-throughput determination of enantiomorphic excess.

References

  1. Brazda, P., Palatinus, L. & Babor, M. Science 364, 667–669 (2019).

    Article  CAS  PubMed  Google Scholar 

  2. Klar, P. B. et al. Nat. Chem. 15, 848–855 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Rietveld, I. B., Painsecq, F., Jandl, C., Stam, D. & Coquerel, G. Cryst. Growth Des. 24, 5893–5897 (2024).

    Article  CAS  Google Scholar 

  4. Hu, J., Dong, Z., Chu, C. & Ma, Y. Nat. Chem. https://doi.org/10.1038/s41557-025-01950-5 (2025).

    Article  PubMed  Google Scholar 

  5. Gemmi, M. et al. ACS Cent. Sci. 5, 1315–1329 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Cichocka, M. O., Angstrom, J., Wang, B., Zou, X. & Smeets, S. J. Appl. Cryst. 51, 1652–1661 (2018).

    Article  CAS  Google Scholar 

  7. Plana-Ruiz, S. et al. Ultramicroscopy 211, 112951 (2020).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Lukas Palatinus.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Palatinus, L. Determining chirality in crystalline powders through 3D electron diffraction. Nat. Chem. 17, 1813–1814 (2025). https://doi.org/10.1038/s41557-025-02006-4

Download citation

  • Published:

  • Version of record:

  • Issue date:

  • DOI: https://doi.org/10.1038/s41557-025-02006-4

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing