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Bringing biocatalysis into teaching labs

Catalysis has been a standard topic taught in university chemistry courses over the past century yet biocatalysis — or enzyme catalysis — has only recently been integrated into standard chemistry curriculum despite its broad applicability in industry. In a fourth year undergraduate research project course, students can now choose to explore interesting chemical transformations in the lab using biocatalysis instead of traditional synthetic chemistry approaches.

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Fig. 1: Timeline for the ten-week Chem4P project at the University of Edinburgh.
Fig. 2: Reaction scheme describing the published biocatalytic deprotectase cascade developed by two Chem4P cohorts (ref. 13).

References

  1. Ertl, G. Angew. Chem. Int. Ed. 47, 3524–3535 (2008).

    Article  Google Scholar 

  2. Huang, P.-S., Boyken, S. E. & Baker, D. Nature 537, 320–327 (2016).

    Article  PubMed  Google Scholar 

  3. Arnold, F. H. Angew. Chem. Int. Ed. 58, 14420–14426 (2019).

    Article  Google Scholar 

  4. Bell, E. L. et al. Nat. Rev. Methods Primers 1, 44 (2021).

    Article  Google Scholar 

  5. Romero, E. O. et al. JACS Au 3, 2073–2085 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Savile, C. K. et al. Science 329, 305–309 (2010).

    Article  PubMed  Google Scholar 

  7. Huffman, M. A. et al. Science 366, 1255–1259 (2019).

    Article  PubMed  Google Scholar 

  8. Etzkorn, F. A. & Ferguson, J. L. Angew. Chem. Int. Ed. 62, e202209768 (2023).

    Article  Google Scholar 

  9. Weise, N. J. & France, S. P. JACS Au 5, 2932–2938 (2025).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Kennedy, L. et al. Faraday Discuss. 252, 174–187 (2024).

    Article  PubMed  PubMed Central  Google Scholar 

  11. McCluskey, A. R., Rivera, M. & Mey, A. S. J. S. Nat. Chem. 16, 1383–1384 (2024).

    Article  PubMed  Google Scholar 

  12. Jumper, J. et al. Nature 596, 583–589 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  13. Bornscheuer, U. T. Faraday Discuss. 252, 507–515 (2024).

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

L.K. thanks the School of Chemistry, University of Edinburgh, the EaSI-CAT Centre for Doctoral Training and Syngenta for PhD funding.

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Correspondence to Dominic J. Campopiano.

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Kennedy, L., Campopiano, D.J. Bringing biocatalysis into teaching labs. Nat. Chem. 18, 1–3 (2026). https://doi.org/10.1038/s41557-025-02032-2

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