Extended Data Fig. 5: Fitness declines decelerate during mutation accumulation as a result of idiosyncratic epistasis.
From: Idiosyncratic epistasis creates universals in mutational effects and evolutionary trajectories
a, A total of 5000 fitness trajectories of mutation accumulation simulated in the GFP landscape, with the average trajectory shown in black, at each step when the trajectory number exceeds 10. b, A total of 350 fitness trajectories of mutation accumulation simulated in the RNA stability landscape, with the average trajectory shown in black. The dotted lines indicate the mean phenotypic value of all genotypes in the landscape, excluding non-active genotypes in the GFP landscape. For comparison, the dashed line in (a) or (b) represents the predicted linear decline given the slope in the first mutational step.
