Extended Data Fig. 6: Impact of fusions on diversification.
From: Spontaneous cell fusions as a mechanism of parasexual recombination in tumour cell populations
a. Estimates of fusion probabilities from in vitro data, with assumptions of no proliferation of hybrids, or proliferation at the same rates as the parental cells. b. Estimates of fusion probabilities from in vivo data for Gompertz and Logistic growth. c-e. Comparisons are drawn between results of in silico simulations involving mutations only versus mutation and fusion. Clonal diversity is captured by Shannon (c), Simpson (d) and GDI (c) diversity indexes. Mutation and fusion rates are indicated in the figures. Indicated p values denote the results for Kolmogorov-Smirnov test for the final timepoint of simulations (c, d), or for the all of the <1 q values (e); growth rate a=0.67/day; carrying capacity K=104 cells; number of genes G=300.
