Extended Data Fig. 8: Impact of population size, cell turnover and starting genetic heterogeneity on diversification by fusion-mediated recombination.
From: Spontaneous cell fusions as a mechanism of parasexual recombination in tumour cell populations
a. Exploration of the impact of maximal tumor population size (carrying capacity) on diversification over indicated mutation and fusion rates. Left: carrying capacity K=104 cells; Right: carrying capacity K=106 cells; growth rate a=0.67/day; number of genes G=300 b. Exploration of the impact of tumor proliferation/turnover rates on diversification over indicated mutation and fusion rates; carrying capacity K=104 cells; number of genes G=50 c. Relationship between the initial clonal richness, and clonal richness at the indicated mutation and fusion rates. In all the panels, clonal richness at the end of the 1095 days of in silico growth is depicted; growth rate a=0.67/day; carrying capacity K=104 cells; number of genes G=300.
