Extended Data Fig. 3: CpH methylation is specific to brain tissues across vertebrates.
From: The emergence of the brain non-CpG methylation system in vertebrates
Sequence motifs found surrounding the highest methylated CpH positions in each sample. CpH positions were required to have a coverage ≥ 10x. hpf = embryo hours post fertilization. Sox10+ cells correspond to developmental neural crest cells in zebrafish. The motif found in the zebrafish brain sample corresponds to the satellite repeat MOSAT, a unique type of non-CpG methylation in zebrafish66. (b) Gene Ontology enrichments for genes showing the highest and lowest gene body methylation levels in the CpA context, as defined by belonging to the top and bottom deciles in each species and tissue. (c) Gene Ontology enrichments for genes showing the highest and lowest methylated levels in the CpG context.
