Extended Data Fig. 7: Oxford grid showing associations between 50 gene segments of bony vertebrate chromosomes and chordate linkage groups (CLGs).
From: Deeply conserved synteny resolves early events in vertebrate evolution
Given the evident localization of orthologs along bony vertebrate chromosomes shown in the ‘Oxford’ dotplots of Fig. 1 and Extended Data Figs. 2 and 3, we assessed the significance of associations between sub-chromosomal regions and the chordate linkage groups. Each vertebrate chromosome was divided into overlapping 50 gene windows (offset by 25 genes). Only 6,843 genes with amphioxus-bony vertebrate mutual best hits are used. Circle areas are proportional to the number of orthologous genes for each chromosome-CLG pair, and the color indicates the significance of the association relative to a null model in which the position of the orthologous genes are randomly shuffled. Comparing Extended Data Figs. 6 and 7 shows additional significant associations that are missed based on whole chromosome analyses.
