Extended Data Fig. 5: Comparisons in computational simulations with various parameters and impact of tumour boundary shape on SCNA burden.
From: Selection of metastasis competent subclones in the tumour interior
a, Necrotic fraction in central versus marginal biopsies in simulations with varying d_nec and p_adv values. b, Number of SCNAs in central versus marginal biopsies in simulations with varying d_nec and p_adv values. c, Number of SCNAs in less versus more necrotic regional biopsies in simulations with varying d_nec and p_adv values. d, Number of SCNAs in central (‘At.Centre’, n = 735) versus marginal (‘At.Margin’, n = 271) biopsies, in tumours with less versus more circularity at the tumour boundary. e, Average subclone birth time relative to the age of the tumour, in tumours with smaller versus larger circularity at the tumour boundary (Less circular: n = 989, more circular: n = 1106).
