Extended Data Fig. 6: Comparison between simulations with or without necrosis.
From: Selection of metastasis competent subclones in the tumour interior
a, Spatial pattern of subclones in a representative simulated tumour without necrosis. Founder clone is in grey while other subclones are in randomly assigned colours. b, Number of SCNAs in central (‘At.Centre’, n = 1922) versus marginal (‘At.Margin’, n = 572) biopsies. c, Spatial pattern of subclones in a representative simulated tumour with necrosis. Tumour areas in yellow are necrotic. Founder clone is in grey while other subclones are in randomly assigned colours. d, Spatial maps of the birth time of subclones relative to the age of the simulated tumour. Darker blue reflects later birth. (i) simulations without necrosis; (ii) simulations with necrosis.
