Fig. 2: Visualization of the GAMM with epigenetic states generated from the EPM model using CpG sites highly correlated to chronological age (absolute r > 0.7).
From: Hibernation slows epigenetic ageing in yellow-bellied marmots
a, Changes in the epigenetic state (or epigenetic age) as individuals age. Points are actual data, while lines are the predictions from the model. b, Predictions generated with the partial effect of date of year (cyclic cubic smoother spline) on epigenetic state. The black horizontal bar represents when samples were collected and most of the marmot active season. c, Predictions generated with the partial effect of chronological age (cubic smoother spline) on epigenetic state. Buffers illustrate the 95% confidence intervals.
