Fig. 5: Limited evidence for deleterious effects of inversions.
From: Chromosomal inversion polymorphisms shape the genomic landscape of deer mice
a, Distances between inversion breakpoints (for 13 inversions with localized breakpoints) and the nearest transcriptional start site (TSS). Two inversions (inv18.0, inv9.1) with breakpoints disrupting protein-coding genes are highlighted. b, pN/pS and πN/πS computed in 500 kb windows, shown for inversion versus standard haplotypes and whole-genome (wg) regions excluding the inversions. Number of windows: n = 8–42 (inversions); n = 2,725 (whole genome). Boxes indicate upper and lower quartiles; centre line represents median; whiskers extend to minimum and maximum values within 1.5× interquartile range. Differences between inversion and standard haplotypes in pN/pS and πN/πS are all nonsignificant (two-sided t-test: P > 0.05), and neither inversions nor standard haplotypes are enriched for pN/pS and πN/πS compared with the whole genome (one-sided t-test: P > 0.05).
